Microfluidic microvessel-on-chip systems provide a useful tool for studying vascular-related biology and disease in vitro. Led by Prof.Shery Huang (CTO), researchers developed rounded microvessels embedded in an extracellular matrix, enabling live-cell imaging and precise tracking of cellular dynamics within a 3D environment. Coupled with image-assisted analysis pipelines, this platform allows quantitative and reproducible measurement of cell-microenvironment interactions, including transmigration, spatial localization, and dynamic behavior.
At Replicam, this expertise can be leveraged to enhance our Brain-OPTIMATM by integrating vascular networks and advanced imaging pipelines. By combining microvessels with organoids, we can study disease cell behavior, pathogen invasion, and drug kinetics in real time, creating more physiologically relevant models. This approach provides a path toward high-resolution, data-driven insights into tissue-microenvironment interactions, supporting applications in drug discovery, personalized medicine.
